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折扣/货期| 货号：GTX84288 | 规格：100μl | 目录价：￥7300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
IRF3 antibody [4D4]
别名:
interferon regulatory factor 3 , IIAE7
反应种属:
Human
宿主来源:
Mouse
实验应用:
FCM, ICC/IF, IHC-P, WB
同种型:
IgG2a
免疫原:
Full length human recombinant protein of human IRF3 (NP_001562) produced in HEK293T cell.
克隆性:
Monoclonal
克隆号:
4D4
纯化方式:
Purified by affinity chromatography
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
47
产品形式:
Liquid
存储溶液:
PBS, 1% BSA, 50% Glycerol, 0.02% Sodium azide.
生产商:
GeneTex
功能与背景:
Mediates interferon-stimulated response element (ISRE) promoter activation. Functions as a molecular switch for antiviral activity. DsRNA generated during the course of an viral infection leads to IRF3 phosphorylation on the C-terminal serine/threonine cluster. This induces a conformational change, leading to its dimerization, nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of genes under the control of ISRE. The complex binds to the IE and PRDIII regions on the IFN-alpha and IFN-beta promoters respectively. IRF-3 does not have any transcription activation domains.
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