Ixazomib [MLN2238]-抑制剂-深圳欣博盛生物科技有限公司

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Ixazomib [MLN2238]

品牌：Adipogen

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说明书

折扣/货期

货号：AG-CR1-3670-M001	规格：1 mg	目录价：￥480
货号：AG-CR1-3670-M005	规格：5 mg	目录价：￥1800
货号：AG-CR1-3670-M025	规格：25 mg	目录价：￥5400

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Ixazomib [MLN2238]

别名:

(R)-1-(2-(2,5-Dichlorobenzamido)acetamido)-3-methylbutylboronic acid

产品描述:

Potent selective and reversible proteasome inhibitor (all proteolytic subunits). Targets the chymotrypsin-like beta5 subunit of the constitutive 20S proteasome (IC50=3.4nM). Cross-reacts and inhibits the trypsin-like beta2 subunit (IC50=3.5µM) and the caspase-like/peptidyl-glutamyl peptide-hydrolyzing (PGPH) beta1 subunit (IC50=0.03µM). Anticancer compound effective in cell-based assays, in xenografts and against multiple myeloma in vivo. In vitro, induces cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma. Biologically active form of the prodrug MLN9708 (Prod. No. AG-CR1-3671). Exhibits improved pharmacodynamics and antitumor activity compared to bortezomib (Prod. No. AG-CR1-3602) in various B cell lymphoma models, due to a greater tumor to blood ratio of proteasome inhibition that ultimately translates into improved tumor pharmacodynamic response and antitumor activity in several tumor xenograft models.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

361

产品形式:

solid

产地:

瑞士

纯度:

>98% (HPLC)