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折扣/货期| 货号：AG-CR1-3671-M001 | 规格：1 mg | 目录价：￥420 |
| 货号：AG-CR1-3671-M005 | 规格：5 mg | 目录价：￥1260 |
| 货号：AG-CR1-3671-M025 | 规格：25 mg | 目录价：￥4440 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Ixazomib citrate [MLN9708]
别名:
(R)-2,2'-(2-(1-(2-(2,5-Dichlorobenzamido)acetamido)-3-methylbutyl)-5-oxo-1,3,2-dioxaborolane-4,4-diyl)diacetic acid
产品描述:
Potent selective and reversible proteasome inhibitor (all proteolytic subunits). Targets the chymotrypsin-like beta5 subunit of the constitutive 20S proteasome (IC50=3.4nM). Cross-reacts and inhibits the trypsin-like beta2 subunit (IC50=3.5µM) and the caspase-like/peptidyl-glutamyl peptide-hydrolyzing (PGPH) beta1 subunit (IC50=0.03µM). Anticancer compound effective in cell-based assays, in xenografts and against multiple myeloma in vivo. In vitro, induces cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma. Prodrug that rapidly hydrolyzes to MLN2238 (Prod. No. AG-CR1-3670). Exhibits improved pharmacodynamics and antitumor activity compared to bortezomib (Prod. No. AG-CR1-3602) in various B cell lymphoma models, due to a greater tumor to blood ratio of proteasome inhibition that ultimately translates into improved tumor pharmacodynamic response and antitumor activity in several tumor xenograft models.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
517.1
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>95% (1H-NMR)
CAS号:
1239908-20-3
分子式:
C20H23BCl2N2O9
溶解度:
Soluble in DMSO (5mg/ml) or DMF (5mg/ml). Poorly soluble in aqueous buffers.
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