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Kdo2-Lipid A (ready-to-use)

品牌：Adipogen

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说明书

折扣/货期

货号：AG-CU1-0001-M001

规格：1 mg

目录价：￥1800

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Kdo2-Lipid A (ready-to-use)

别名:

(3-Deoxy-D-manno-octulosonic acid)2-Lipid A

产品描述:

Defined substructure of the Re mutant of lipopolysaccharide (LPS) [1]. Endotoxin activity equal to Re LPS [1]. Strong activator (<10ng/ml) of macrophages via toll-like receptor 4 (TLR4) [1, 2, 3, 4, 9]. Does not activate TLR2 [5] or other TLRs as determined with splenocytes and macrophages from TLR4 deficient mice by IL-6 ELISA [1,4]. Facilitates the structural analysis of its complexes with signaling receptors, such as TLR4/MD2 [1,2] and CD14 [7]. Kdo2-Lipid A was used in a recent animal atherosclerosis model [6]. Induces sphingolipid biosynthesis, which is essential for induction of autophagy [8].

宿主来源:

Isolated and purified from E. coli K12 heptose-deficient strain WBB06 (Re mutant).

产品浓度:

0.5mg/ml. Vial contains 2 ml.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

2326.7

产品形式:

liquid