Ganglioside GM1 . sodium salt (bovine brain)-脂质-深圳欣博盛生物科技有限公司

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Ganglioside GM1 . sodium salt (bovine brain)

品牌：Adipogen

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说明书

折扣/货期

货号：AG-CN2-9000-M001	规格：1 mg	目录价：￥1020
货号：AG-CN2-9000-M005	规格：5 mg	目录价：￥3360
货号：AG-CN2-9000-M010	规格：10 mg	目录价：￥5280

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Ganglioside GM1 . sodium salt (bovine brain)

别名:

GM1 . Na; Monosialoganglioside GM1 . Na

产品描述:

Gangliosides are acidic glycosphingolipids that form lipid rafts in the outer leaflet of the cell plasma membrane, especially in neuronal cells in the central nervous system. They participate in cellular proliferation, differentiation, adhesion, signal transduction, cell-to-cell interactions, tumorigenesis and metastasis. The accumulation of gangliosides has been linked to several diseases. Ganglioside GM1 is a major sialoglycolipid of neuronal membranes that modulates calcium homeostasis and which is important for neuronal plasticity and repair mechanisms. It binds to cholera toxin B subunit, resulting in stimulation of adenylyl cyclase in a wide variety of cell types. After cholera toxin binds to membrane associated Monosialoganglioside GM1, the A subunit of cholera toxin is translocated to the cell interior, where it catalyzes the ADP ribosylation of the membrane associated Gs subunit of adenylyl cyclase. In addition, binding of cholera toxin to monosialoganglioside GM1 causes translocation of NF-kappaB and activation of dendritic cells. E. coli heat-labile enterotoxin (LT) is structurally and functionally similar to cholera toxin and binds GM1 as well. GM1 has also been shown to improve Parkinson's disease symptoms and slow it's progression.

宿主来源:

Isolated from bovine brain.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

1545.8 . 23.0 (calculated on sphingosine C18:1 and stearic acid)

产品形式:

solid

存储溶液:

Lyophilized.