KillerTRAIL, Soluble (human) (rec.)-其他重组蛋白-深圳欣博盛生物科技有限公司

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KillerTRAIL, Soluble (human) (rec.)

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-40T-0001-3050	规格：3 x 50 ug	目录价：￥9840
货号：AG-40T-0001-C050	规格：50 ug	目录价：￥4920
货号：AG-40T-0001-C500	规格：500 ug	目录价：￥20400

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

KillerTRAIL, Soluble (human) (rec.)

别名:

TRAIL; Apo-2L; TNFSF10; CD253

产品描述:

TNF-related apoptosis-inducing ligand (TRAIL; Apo2L;CD253; TNFSF10) is a type II transmembrane protein of about 34kDa. Like most members of the tumor necrosis factor (TNF) superfamily of cytokines TRAIL can be cleaved at the cell surface by metalloproteases to form a soluble molecule. Active TRAIL forms trimers and specifically binds to five distinct receptors: TRAIL-R1 (DR4; Apo2;CD261; TNFRSF10A), TRAIL-R2 (DR5; KILLER; TRICK2A;TRICK2B; CD262; TNFRSF10B), TRAIL-R3 (DcR1;LIT; TRID; CD263; TNFRSF10C), TRAIL-R4 (DcR2;TRUNDD; CD264; TNFRSF10D), and osteoprotegerin (OPG; OCIF; TNFRSF11B). Trimerized TRAIL triggers apoptosis upon ligation of cell surface TRAIL-R1 and/or TRAIL-R2 by inducing the formation of the so-called multiprotein death-inducing signaling complex (DISC).

宿主来源:

E. coli

靶标/特异性:

Binds to human TRAIL receptors. Binding to OPG has not been tested experimentally.

产品浓度:

50µg Vials: 0.5 mg/ml500µg Vials: Lot dependent

保存温度:

-20°C

运输温度:

预期分子量:

~24kDa (SDS-PAGE)

产品形式:

liquid

存储溶液:

Liquid. In 20mM HEPES, pH 7.4, 150mM NaCl, 0.005% Tween 20, 1% sucrose, 1mM DTT.

产地:

瑞士

纯度:

>98% (SDS-PAGE)

生物活性:

Potent biologically active trimer. Induces apoptosis in a concentration range of 10-100ng/ml. Note: Does not require a cross-linking enhancer for its potent biological activity. ED50: 20ng/ml (BJAB cells). For cell lines that require extensive cross-linking of the TRAIL-Rs for killing (e.g. Jurkat) use SuperKillerTRAIL™ (Prod. No. AG-40T-0002).

内毒素水平:

<0.01EU/µg purified protein (LAL test; Lonza).

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