LAMP1 Antibody: PerCP-单抗-深圳欣博盛生物科技有限公司

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LAMP1 Antibody: PerCP

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SMC-140D-PCP

规格：100 µg

目录价：￥4775.4

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

LAMP1 Antibody: PerCP

别名:

CD107 Antibody, CD107a Antibody, LAMPA Antibody, LGP120 Antibody, IgpA Antibody, Lysosome-associated membrane glycoprotein 1 Antibody, CD107 antigen-like family member A Antibody, 120 kDa lysosomal membrane glycoprotein Antibody, Lamp-1 Antibody

产品描述:

Mouse Anti-Rat LAMP1 Monoclonal IgG1

反应种属:

Human | Mouse | Rat | Hamster

宿主来源:

Mouse

实验应用:

WB | ICC/IF | IP

靶标/特异性:

Detects ~120kDa.

同种型:

IgG1

推荐稀释度:

WB (1:1000), ICC/IF (1:1000); optimal dilutions for assays should be determined by the user.

免疫原:

Rat liver lysosomal membrane preparations

免疫原种属:

Rat

克隆性:

Monoclonal

克隆号:

Ly1C6

纯化方式:

Protein G Purified

偶联:

PerCP

产品浓度:

1 mg/ml

保存温度:

Conjugated antibodies should be stored according to the product label

运输温度:

Blue Ice or 4ºC

存储溶液:

PBS pH7.4, 50% glycerol, 0.09% sodium azide *Storage buffer may change when conjugated

产地:

加拿大

功能与背景:

Lysosme associated membrane proteins, or LAMP1 and LAMP2, are major constituents of the lysosomal membrane. The two have closely related structures, with 37% sequence homology (2). They are both transmembrane glycoproteins that are localized primarily in lysosomes and late endosomes. Newly synthesized molecules are mostly transported from the trans-Golgi network directly to endosomes and then to lysosomes. A second pathway involves the lamps being delivered from the Golgi to the cell surface, and then along the endocytic pathway to the lysosomes. A minor pathway involves transport via the plasma membrane (3). Upon stimulation, a rapid translocation of intracellular LAMPs to the cell membrane is dependent on a carboxyl¬terminal tyrosine ba based motif (YXXI) (1). If there is a disturbance in this spacing, lysosome localization of LAMP1 is abolished and the mutant protein then cycles between the membrane and the endosome (3). This stimulation has also been shown to have an associated release of histamine, leukotriene C (4) and prostaglandin D (2), which shows that LAMP-1 and LAMP-2 are activation markers for normal mast cells (1). They have also been linked to the inflammatory response in that they promote adhesion of human peripheral blood mononuclear cells (PBMC) to vascular endothelium, and therefore possibly the adhesion of PBMC to the site of inflammation (4).

Accession #:

NP_036989.1