官网链接
折扣/货期| 货号：GTX628139-S | 规格：25μl | 目录价：￥1700 |
| 货号：GTX628139 | 规格：100μl | 目录价：￥4000 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Lin28A antibody [GT1086]
别名:
lin-28 homolog A , CSDD1 , LIN-28 , LIN28 , ZCCHC1 , lin-28A
反应种属:
Human
宿主来源:
Mouse
实验应用:
FCM, ICC/IF, IHC-P, WB
同种型:
IgG2b
免疫原:
Recombinant protein encompassing a sequence within the center region of human Lin28A. The exact sequence is proprietary.
克隆性:
Monoclonal
克隆号:
GT1086
纯化方式:
Affinity purified by Protein G.
偶联:
Unconjugated
产品浓度:
1 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
23
产品形式:
Liquid
存储溶液:
PBS, no preservatives.
生产商:
GeneTex
功能与背景:
Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression (By similarity). Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells. In contrast, LIN28A down-regulation in neural stem cells by miR-125, allows the processing of pre-let-7. Specifically recognizes the 5'-GGAG-3' motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5'-GGAG-3' motif in the terminal loop, leading to their terminal uridylation and subsequent degradation.
您可能感兴趣的产品
Anti-Carbamylation (Homocitrulline) Monoclonal Antibody - Biotinylated (Clone 1C6)
货号：44745
Hyperoxidized Peroxiredoxin-3 Monoclonal Antibody - Biotinylated (Clone 5H7c)
货号：44744
Histone H3 (Citrullinated R2 + R8 + R17) Monoclonal Antibody - Biotinylated (Clone 11D3)
货号：44743
Anti-Citrulline Monoclonal Antibody (Clone 1D9) - HRP
货号：44511
Chk1 (phospho Ser317) antibody [HL4313]
货号：GTX643560
SLC25A1 antibody [HL4228]
货号：GTX643061
Latrophilin 2 antibody [HL4090]
货号：GTX642529
PSD93 antibody [GT126]
货号：GTX642326
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询