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折扣/货期| 货号：22211-1 mg | 规格：1 mg | 目录价：￥482 |
| 货号：22211-10 mg | 规格：10 mg | 目录价：￥3162 |
| 货号：22211-25 mg | 规格：25 mg | 目录价：￥6727 |
| 货号：22211-5 mg | 规格：5 mg | 目录价：￥1715 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
LY2090314
产品描述:
A potent and selective inhibitor of GSK3 (IC50s = 1.5 and 0.9 for human recombinant GSK3α and GSK2β, respectively); has >10-fold selectivity for GSK3 against a panel of 40 kinases at a concentration of 20 μM; induces time-dependent stabilization of β-catenin total protein and activates Wnt signaling in vitro; has potent antiproliferative activity in BRAF wild-type/NRAS mutant and BRAF mutant melanoma cell lines (IC50s = 6.0-11.8 nM) but has limited to no activity in non-melanoma cell lines (IC50s = 430 to >20,000 nM); knockdown of β-catenin in A375 and M14 melanoma cells induces LY2090314 resistance in vitro; reduces tumor volume in a murine A375 xenograft model as a single agent and synergizes with decabarzine for a greater antitumor effect
保存温度:
-20
运输温度:
-20
预期分子量:
512.5
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
603288-22-8
分子式:
C28H25FN6O3
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