MAP3K14 antibody-多抗-深圳欣博盛生物科技有限公司

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MAP3K14 antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX27204

规格：50μg

目录价：￥4300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

MAP3K14 antibody

反应种属:

Human

宿主来源:

Rabbit

实验应用:

IP, WB

同种型:

IgG

免疫原:

Recombinant fragment, corresponding to amino acids 795-953 of Human NIK.

克隆性:

Polyclonal

克隆号:

纯化方式:

Protein A purified

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, 0.1% Sodium azide.

生产商:

GeneTex

功能与背景:

NIK (NF-kB-inducing kinase) is a member of the MAP kinase kinase kinase family that binds TRAF2 and stimulates NF-kB activity. NIK, initially isolated from a human B cell cDNA library, contains 795 amino acids with an apparent molecular weight of slightly more than 97 kDa on SDS gel. NIK is a serine/threonine kinase and its kinase activity contributes to I B phosphorylation. The carboxyl terminal segment of NIK binds TRAF2. A mutant NIK with intact carboxyl terminus but without the two lysine residues at its catalytic domain serves as a dominant-negative inhibitor for NF-kB activation. NIK also interacts with TRAF6 and mediates IL-1-induced NF-kB activation.

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