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折扣/货期| 货号：60-515 | 规格：400 ul | 目录价：￥8687.25 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
MBD4 Antibody
别名:
Methyl-CpG-binding domain protein 4, 322-, Methyl-CpG-binding endonuclease 1, Methyl-CpG-binding protein MBD4, Mismatch-specific DNA N-glycosylase, MBD4, MED1
反应种属:
Human
宿主来源:
Rabbit
实验应用:
WB
同种型:
Rabbit Ig
克隆性:
Polyclonal
纯化方式:
This antibody is purified through a protein A column, followed by peptide affinity purification.
偶联:
Unconjugated
产品浓度:
batch dependent
保存温度:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
Supplied in PBS with 0.09% (W/V) sodium azide.
产地:
美国
生产商:
Prosci
功能与背景:
DNA methylation is the major modification of eukaryotic
genomes and plays an essential role in mammalian development. Human
proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of
nuclear proteins related by the presence in each of a methyl-CpG
binding domain (MBD). Each of these proteins, with the exception of
MBD3, is capable of binding specifically to methylated DNA. MBD4
may function to mediate the biological consequences of the
methylation signal. In addition, MBD4 has protein sequence
similarity to bacterial DNA repair enzymes and thus may have some
function in DNA repair. Further, MBD4 gene mutations are detected
in tumors with primary microsatellite-instability (MSI), a form of
genomic instability associated with defective DNA mismatch repair,
and MBD4 gene meets 4 of 5 criteria of a bona fide MIS target gene.
Accession #:
O95243
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