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折扣/货期| 货号：60-514 | 规格：400 ul | 目录价：￥8687.25 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
RBL1 Antibody
别名:
Retinoblastoma-like protein 1, 107 kDa retinoblastoma-associated protein, p107, pRb1, RBL1
反应种属:
Human
宿主来源:
Rabbit
实验应用:
WB
同种型:
Rabbit Ig
克隆性:
Polyclonal
纯化方式:
This antibody is purified through a protein A column, followed by peptide affinity purification.
偶联:
Unconjugated
产品浓度:
batch dependent
保存温度:
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
Supplied in PBS with 0.09% (W/V) sodium azide.
产地:
美国
生产商:
Prosci
功能与背景:
The protein encoded by this gene is similar in sequence
and possibly function to the product of the retinoblastoma 1 (RB1)
gene. The RB1 gene product is a tumor suppressor protein that
appears to be involved in cell cycle regulation, as it is
phosphorylated in the S to M phase transition and is
dephosphorylated in the G1 phase of the cell cycle. Both the RB1
protein and the product of this gene can form a complex with
adenovirus E1A protein and SV40 large T-antigen, with the SV40
large T-antigen binding only to the unphosphorylated form of each
protein. In addition, both proteins can inhibit the transcription
of cell cycle genes containing E2F binding sites in their
promoters. Due to the sequence and biochemical similarities with
the RB1 protein, it is thought that the protein encoded by this
gene may also be a tumor suppressor. Two transcript variants
encoding different isoforms have been found for this gene.
Accession #:
P28749
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