MBIMPH F-Analog 1 . hydrochloride-抑制剂-深圳欣博盛生物科技有限公司

首页产品中心抑制剂

MBIMPH F-Analog 1 . hydrochloride

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CR1-3908-M001	规格：1 mg	目录价：￥1800
货号：AG-CR1-3908-M005	规格：5 mg	目录价：￥7200

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

MBIMPH F-Analog 1 . hydrochloride

别名:

MBIMPH Fluorinated Analog 1; 3-Fluoro-N-hydroxy-4-((2-methyl-1H-benzo[d]imidazol-1-yl)methyl)benzamide

产品描述:

Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =3nM). Displays high selectivity over all other HDACs (IC50=0.03-20µM). Induces cellular alpha-tubulin, but not histone H3 hyperacetylation in Neuro-2a cells. Promotes mitochondrial transport. Shows improved kinetics and biochemical potency against HDAC6 compared to tubastatin A (AG-CR1-3900). HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

299.3 . 36.5

产品形式:

solid

产地:

瑞士

纯度:

>95% (HPLC)