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MCM4 Antibody

品牌：ProSci LLC

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说明书

折扣/货期

货号：15-035

规格：100 uL

目录价：￥7651.8

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

MCM4 Antibody

别名:

MCM4, NKCD, CDC21, CDC54, NKGCD, hCdc21, P1-CDC21

反应种属:

Human,Mouse,Rat

宿主来源:

Rabbit

实验应用:

WB,IHC

同种型:

IgG

克隆性:

Polyclonal

纯化方式:

Affinity purification

偶联:

Unconjugated

产品浓度:

batch dependent

保存温度:

Store at -20˚C. Avoid freeze / thaw cycles.

运输温度:

Blue Ice

产品形式:

Liquid

存储溶液:

PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

产地:

美国

生产商:

Prosci

功能与背景:

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported.

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