MDMX antibody [2D10F4]-单抗-深圳欣博盛生物科技有限公司

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MDMX antibody [2D10F4]

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX83335

规格：100μl

目录价：￥5600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

MDMX antibody [2D10F4]

别名:

MDM4 regulator of p53 , HDMX , MDMX , MRP1

反应种属:

Human

宿主来源:

Mouse

实验应用:

ELISA, ICC/IF, IHC-P, WB

同种型:

IgG1

免疫原:

Purified recombinant fragment of human MDM4 expressed in E. Coli.

克隆性:

Monoclonal

克隆号:

2D10F4

纯化方式:

Unpurified

偶联:

Unconjugated

产品浓度:

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

Ascites, 0.03% Sodium azide.

生产商:

GeneTex

功能与背景:

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

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