MEK3 (phospho Ser189) antibody-多抗-深圳欣博盛生物科技有限公司

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MEK3 (phospho Ser189) antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX79010

规格：100μg

目录价：￥5300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

MEK3 (phospho Ser189) antibody

别名:

MAP2K3,MAPKK3,MEK3,MKK3,PRKMK3,SAPKK2,mitogenactivated protein kinase kinase 3,mitogen-activated protein kinase kinase 3

反应种属:

Human

宿主来源:

Rabbit

实验应用:

IHC-P, WB

同种型:

IgG

免疫原:

The antiserum was produced against synthesized phosphopeptide derived from human MKK3 around the phosphorylation site of serine 189 (V-D-Sp-V-A).

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by sequential chromatography on phospho- and non-phospho-peptide affinity columns.

偶联:

Unconjugated

产品浓度:

Batch dependent (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

PBS, 150mM NaCl, 0.5% BSA, 50% glycerol (Please contact us for BSA-free format), 0.02% Sodium azide.

生产商:

GeneTex

功能与背景:

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]

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