Mertk Antibody-多抗-深圳欣博盛生物科技有限公司

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Mertk Antibody

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：F53189-0.08ML	规格：0.08 ml	目录价：￥2962
货号：F53189-0.4ML	规格：0.4 ml	目录价：￥6344

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Mertk Antibody

产品描述:

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

反应种属:

Mouse, Rat

宿主来源:

Rabbit

实验应用:

WB, ELISA

同种型:

Rabbit Ig

免疫原:

This Mertk antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 946-980 amino acids from the C-terminal region of mouse Mertk.

克隆性:

Polyclonal (rabbit origin)

纯化方式:

Antigen affinity

保存温度:

Aliquot the Mertk antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

产品形式:

Antigen affinity purified

存储溶液:

In 1X PBS, pH 7.4, with 0.09% sodium azide

产地:

美国