Uhrf1 Antibody-多抗-深圳欣博盛生物科技有限公司

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Uhrf1 Antibody

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：F53188-0.08ML	规格：0.08 ml	目录价：￥2962
货号：F53188-0.4ML	规格：0.4 ml	目录价：￥6344

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Uhrf1 Antibody

产品描述:

Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD- type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the ubiquitination of target proteins such as histone H3 and PML. It is still unclear how E3 ubiquitin-protein ligase activity is related to its role in chromatin in vivo. May be involved in DNA repair.

反应种属:

Mouse

宿主来源:

Rabbit

实验应用:

WB, ELISA

同种型:

Rabbit Ig

免疫原:

This mouse Uhrf1 antibody was produced from a rabbit immunized with a KLH conjugated synthetic peptide between 596-628 amino acids from the C-terminal region of mouse Uhrf1.

克隆性:

Polyclonal (rabbit origin)

纯化方式:

Antigen affinity

保存温度:

Aliquot the Uhrf1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

产品形式:

Antigen affinity purified

存储溶液:

In 1X PBS, pH 7.4, with 0.09% sodium azide

产地:

美国