MLN4924 [NAE Inhibitor]-抑制剂-深圳欣博盛生物科技有限公司

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MLN4924 [NAE Inhibitor]

品牌：Adipogen

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说明书

折扣/货期

货号：AG-CR1-3703-M005	规格：5 mg	目录价：￥1440
货号：AG-CR1-3703-M025	规格：25 mg	目录价：￥6000

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

MLN4924 [NAE Inhibitor]

别名:

Pevonedistat; Nedd8 E1 Activating Enzyme Inhibitor; TAK924

产品描述:

Adenosine 5'-monophosphate (AMP) analog. Potent, selective and cell permeable inhibitor of Nedd8 E1 Activating Enzyme (NAE) (IC50=4.7nM). NEDD8 is an ubiquitin-like protein whose activity is required to activate cullin-RING ubiquitin E3 ligases (CRLs) responsible for the ubiquitination and proteasome-dependent turnover of certain substrates relevant to cancer cell survival. Anticancer agent with in vitro and in vivo activity. By inhibiting the Neddylation pathway this molecule disrupts cullin-RING ligase activity, leading to inhibition of proliferation or apoptotic death of various human tumor cells through the deregulation of S-phase DNA synthesis. Inhibits related enzymes ubiquitin-activating enzyme (UAE) and SUMO-activating enzyme (SAE) with IC50 values of 1.5 and 8.2µM, respectively. Angiogenesis inhibitor and autophagy inducer. Antiviral agent. Exhibited pronounced antiviral activity against mouse and human cytomegalovirus, herpes simplex virus (HSV)-1 (including multi-drug resistant clinical isolates), HSV-2, adeno and influenza viruses.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

443.5 . 18.0

产品形式:

solid

产地:

瑞士

纯度:

>99%