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折扣/货期| 货号：AG-CR1-3705-M005 | 规格：5 mg | 目录价：￥480 |
| 货号：AG-CR1-3705-M025 | 规格：25 mg | 目录价：￥1920 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Necrosulfonamide
别名:
NSA; (2E)-N-[4-[[(3-Methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenamide
产品描述:
Inhibitor of necroptosis, by blocking mixed lineage kinase domain-like protein (MLKL), a key substrate of receptor-interacting serine-threonine kinase 3 (RIP3). Shown to prevent the MLKL-RIP1-RIP3 necrosome complex from interacting with downstream necrosis effectors. Potent inhibitor of gasdermin D that works well for mice studies. It binds directly to gasdermin D and inhibits the oligomerization of the N-terminus and therefore the pore formation and pyroptosis. Displayed neuroprotective effects after ischemic brain injury, prevented cystine-starvation-induced necroptosis and ferroptosis in human triple negative breast cancer cells and rescued cells from TLR3 ligand-induced death.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
461.5
产品形式:
solid
产地:
瑞士
纯度:
>95%
CAS号:
1360614-48-7
分子式:
C18H15N5O6S2
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