Mononucleosomes (H3.3K27M), Recombinant Human-突变/修饰核小体-深圳欣博盛生物科技有限公司

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Mononucleosomes (H3.3K27M), Recombinant Human

品牌：EpiCypher

官网链接

说明书

折扣/货期

货号：16-0323

规格：100 µg

目录价：￥5100

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Mononucleosomes (H3.3K27M), Recombinant Human

产品描述:

Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B, H3.3 and H4; accession numbers: H2A-P04908; H2B-O60814; H3.3-P84243; H4-P62805) wrapped by 147 base pairs of 601 positioning sequence DNA. Histone H3.3 is a non-allelic replacement found in regions of high chromatin turnover outside of S-phase (e.g. at actively transcribed genes). The substitution of M for K at position 27 is a dominant negative inhibitor of the EZH2 methyltransferase complex PRC2 and is associated with pediatric brain cancer (DIPG) [1]. The nucleosome is the basic subunit of chromatin. The 147 bp 601 sequence, identified by Lowary and Widom [2], has high affinity for histone octamers and is useful for nucleosome assembly.

保存温度:

Stable for six months at -80°C from date of receipt. For best results, aliquot and avoid multiple freeze/thaws.

运输温度:

Dry ice.

产地:

美国

生产商:

EpiCypher

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