Mononucleosomes (H3.3K27M), Recombinant Human, Biotinylated-突变/修饰核小体-深圳欣博盛生物科技有限公司

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Mononucleosomes (H3.3K27M), Recombinant Human, Biotinylated

品牌：EpiCypher

官网链接

说明书

折扣/货期

货号：16-1323

规格：50 µg

目录价：￥5700

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Mononucleosomes (H3.3K27M), Recombinant Human, Biotinylated

产品描述:

Oncogenic Nucleosomes (oncoNucs™) are recombinant nucleosomes assembled using histones with cancer-associated mutations, providing physiologically relevant substrates for cancer research. OncoNucs consist of 147 base pairs of DNA wrapped around an octamer core of histone proteins (two each of H2A, H2B, H3.3 and H4). The 147 bp 601 sequence, identified by Lowary and Widom [1], has high affinity for histone octamers and is useful for nucleosome assembly. H3.3K27M mononucleosome contains a methionine at position 27 on histone H3.3, which is a dominant negative inhibitor of the EZH2 methyltransferase of the PRC2 complex and associated with pediatric brain cancer (DIPG). The DNA in this nucleosome contains a 5’ biotin-TEG group.

宿主来源:

Human

表达系统:

E. coli & synthetic DNA

保存温度:

Stable for six months at -80°C from date of receipt. For best results, aliquot and avoid freeze/thaws.

运输温度:

Dry ice.

产品形式:

1.0 mg/mL mononucleosome in 50.1 µL 10 mM Tris HCl pH 7.5, 25 mM NaCl, 1 mM EDTA, 2 mM DTT, 20% glycerol (27.5 µg protein, 50.0 µg DNA+ protein)

产地:

美国