Mouse Anti-Human IgM antibody [8H6]-单抗-深圳欣博盛生物科技有限公司

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Mouse Anti-Human IgM antibody [8H6]

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品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX01856

规格：500μl

目录价：￥4700

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Mouse Anti-Human IgM antibody [8H6]

别名:

immunoglobulin heavy constant mu , AGM1 , MU , VH

反应种属:

Human

宿主来源:

Mouse

实验应用:

IHC-P, WB

同种型:

IgG2a

免疫原:

Prokaryotic recombinant protein corresponding to a portion of the N terminus of the heavy chain constant region.

克隆性:

Monoclonal

克隆号:

8H6

纯化方式:

Unpurified

偶联:

Unconjugated

产品浓度:

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

Tissue culture supernatant, 0.09% Sodium azide.

生产商:

GeneTex

功能与背景:

Immunoglobulins (Ig) are the antigen recognition molecules of B cells. An Ig molecule is made up of 2 identical heavy chains and 2 identical light chains (see MIM 147200) joined by disulfide bonds so that each heavy chain is linked to a light chain and the 2 heavy chains are linked together. Each Ig heavy chain has an N-terminal variable (V) region containing the antigen-binding site and a C-terminal constant (C) region, encoded by an individual C region gene, that determines the isotype of the antibody and provides effector or signaling functions. The heavy chain V region is encoded by 1 each of 3 types of genes: V genes (see MIM 147070), joining (J) genes (see MIM 147010), and diversity (D) genes (see MIM 146910). The C region genes are clustered downstream of the V region genes within the heavy chain locus on chromosome 14. The IGHM gene encodes the C region of the mu heavy chain, which defines the IgM isotype. Naive B cells express the transmembrane forms of IgM and IgD (see IGHD; MIM 1471770) on their surface. During an antibody response, activated B cells can switch to the expression of individual downstream heavy chain C region genes by a process of somatic recombination known as isotype switching. In addition, secreted Ig forms that act as antibodies can be produced by alternative RNA processing of the heavy chain C region sequences. Although the membrane forms of all Ig isotypes are monomeric, secreted IgM forms pentamers, and occasionally hexamers, in plasma (summary by Janeway et al., 2005).[supplied by OMIM, Aug 2010]

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