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折扣/货期| 货号：GTX70212 | 规格：100μl | 目录价：￥4300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Mre11 antibody [12D7]
别名:
MRE11 homolog, double strand break repair nuclease , ATLD , HNGS1 , MRE11A , MRE11B
产品描述:
MRE11 antibody recognizes MRE11 protein, an enzyme with a predicted molecular weight of ~81 kDa. MRE11 forms the core of the MRN (MRE11-RAD50-NBS1) complex, one of the first components of the DNA damage response (DDR) to DNA double-strand breaks where it recruits other signaling factors required for repair. MRE11 has both exonuclease and endonuclease activities, and is responsible for the DNA binding of the complex.
反应种属:
Human
宿主来源:
Mouse
实验应用:
ELISA, Functional Assay, ICC/IF, IP, PLA, WB
靶标/特异性:
We do not recommend use of this product for Mouse,Rat.
同种型:
IgG1
免疫原:
Amino acids 182-582 of Mre11 expressed in E. coli.
克隆性:
Monoclonal
克隆号:
12D7
纯化方式:
Protein G purified
偶联:
Unconjugated
产品浓度:
0.45 mg/ml (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
产品形式:
Liquid
存储溶液:
PBS, no preservatives.
生产商:
GeneTex
功能与背景:
This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
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