Mre11 antibody [12D7]-单抗-深圳欣博盛生物科技有限公司

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Mre11 antibody [12D7]

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX70212

规格：100μl

目录价：￥4300

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Mre11 antibody [12D7]

别名:

MRE11 homolog, double strand break repair nuclease , ATLD , HNGS1 , MRE11A , MRE11B

产品描述:

MRE11 antibody recognizes MRE11 protein, an enzyme with a predicted molecular weight of ~81 kDa. MRE11 forms the core of the MRN (MRE11-RAD50-NBS1) complex, one of the first components of the DNA damage response (DDR) to DNA double-strand breaks where it recruits other signaling factors required for repair. MRE11 has both exonuclease and endonuclease activities, and is responsible for the DNA binding of the complex.

反应种属:

Human

宿主来源:

Mouse

实验应用:

ELISA, Functional Assay, ICC/IF, IP, PLA, WB

靶标/特异性:

We do not recommend use of this product for Mouse,Rat.

同种型:

IgG1

免疫原:

Amino acids 182-582 of Mre11 expressed in E. coli.

克隆性:

Monoclonal

克隆号:

12D7

纯化方式:

Protein G purified

偶联:

Unconjugated

产品浓度:

0.45 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

产品形式:

Liquid

存储溶液:

PBS, no preservatives.

生产商:

GeneTex

功能与背景:

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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