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折扣/货期| 货号：2125-0.02 mg | 规格：0.02 mg | 目录价：￥1345.5 |
| 货号：2125-0.1 mg | 规格：0.1 mg | 目录价：￥6084 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
MYD88 Antibody
别名:
MYD88 Antibody: Myeloid differentiation primary response 88, MYD88D
反应种属:
Human,Mouse,Rat
宿主来源:
Rabbit
实验应用:
ELISA,WB,IHC-P,IF,IP
同种型:
IgG
克隆性:
Polyclonal
纯化方式:
MYD88 Antibody is affinity chromatography purified via peptide column.
偶联:
Unconjugated
产品浓度:
1 mg/mL
保存温度:
MYD88 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
MYD88 Antibody is supplied in PBS containing 0.02% sodium azide.
产地:
美国
生产商:
Prosci
功能与背景:
MYD88, myeloid differentiation primary response 88, was identified as an innate immune signal transduction adaptor involved in the Toll-like receptor (TLR) and interleukin-1 (IL-1) signaling pathway (1,2,3) and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 functions as an adaptor protein for TLRs and IL-1 receptors, which stimulates IRAKs, IRF7 and TRAF6, leading to NF-κB activation, cytokine secretion and inflammatory response (2, 4,5,6). Nuclear factor-kappa-B activation modulates multiple genes regulating the body's immune reactions and inflammatory responses. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF-κB activation(4,5). MyD88 is also employed as a regulator molecule by IL-18 receptor. Targeted disruption of the MyD88 gene results in loss of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs TLR2 and TLR4 as the signaling receptors(7,8). MyD88 gene is expressed in many tissues.
Accession #:
AAB49967.1
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