官网链接
折扣/货期| 货号：AG-CR1-3901-M001 | 规格：1 mg | 目录价：￥1440 |
| 货号：AG-CR1-3901-M005 | 规格：5 mg | 目录价：￥5760 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Nexturastat A
别名:
4-((1-Butyl-3-phenylureido)methyl)-N-hydroxybenzamide
产品描述:
Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50 =5.02nM). Displays high selectivity over all other HDACs (IC50=3-10µM). Suppresses cell proliferation and promotes apoptosis in B16 cells (GI50=14.3µM) and human lymphoma cells HuT-78. Dose-dependently induces hyperacetylation of alpha-tubulin in B16 murine melanoma cells without elevating histone H3 acetylation. Induces cell cycle arrest in G1. HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
341.4
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
1403783-31-2
分子式:
C19H23N3O3
溶解度:
Soluble in DMSO. Slightly soluble in methanol or ethanol (1mg/ml). Almost insoluble in water.
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询