Nexturastat B-抑制剂-深圳欣博盛生物科技有限公司

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Nexturastat B

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CR1-3902-M001	规格：1 mg	目录价：￥720
货号：AG-CR1-3902-M005	规格：5 mg	目录价：￥2160

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Nexturastat B

别名:

4-((1-Butyl-3-(1H-indazol-6-yl)ureido)methyl)-N-hydroxybenzamide

产品描述:

Cell permeable, potent and selective class IIb HDAC6 inhibitor (IC50=3nM). Displays high selectivity over HDAC1 (300-fold). More soluble analog of nexturastat A (Prod. No. AG-CR1-3901). Suppresses cell proliferation of B16 cells (GI50=14.3µM) and human lymphoma cells HuT-78 at a slightly lower concentration than nexturastat A. Shown to be effective in a mouse melanoma tumor xenograft model, increasing tumor volumes in vivo. Down-regulates the production of IL-10. HDAC6 deacetylates tubulin, HSP90 and the core histones (H2A, H2B, H3, H4). Histone deacetylases act via the formation of large multiprotein complexes. HDAC6 plays an important role in microtubule-dependent cell motility, transcriptional regulation, degradation of misfolded proteins and cell cycle and is involved in autophagy, inflammation, cancer and neurodegeneration.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

381.4

产品形式:

solid

产地:

瑞士

纯度:

>98% (HPLC)