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折扣/货期| 货号：GTX27550 | 规格：50μg | 目录价：￥3200 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
NFkB p50 peptide
别名:
Nuclear Factor Kappa B Subunit 1 , Cvid12 , Ebp-1 , Kbf1 , Nf-Kb1 , Nf-Kappa-B1 , Nf-Kappab , Nfkb-P105 , Nfkb-P50 , Nfkappab , P105 , P50 , Nfkb1
实验应用:
Neutralizing/Inhibition
克隆号:
纯化方式:
Unpurified
偶联:
Unconjugated
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
Dry ice
产品形式:
Liquid
存储溶液:
Serum, 0.01% Sodium azide.
生产商:
GeneTex
功能与背景:
NFkB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. NF-kB is a family of transcription factors that consists of homo- and heterodimers of NFkB1/p50 and RelA/p65 subunits, and controls a variety of cellular events including development and immune responses. All members share a conserved amino-terminus domain that includes dimerization, nuclear localization, and DNA binding regions, and a carboxy-terminal transactivation domain. Serines 529 and 536 in the transactivation domain of RelA/p65 are phosphorylated in response to several stimuli including phorbol ester, IL-1alpha and TNF-alpha as mediated by IkB kinase and p38 MAPK. Serine 529 is located in a negatively charged region (amino acids 422-540) that is phosphorylated in response to phorbol myristate acetate plus calcium ionophore activation. Phosphorylation of serines 529 and 536 is critical for RelA/p65 transcriptional activity. Activated NF-kB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NF-kB has been associated with a number of inflammatory diseases while persistent inhibition of NF-kB leads to inappropriate immune cell development or delayed cell growth.
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