官网链接
折扣/货期| 货号：AG-CR1-3644-M025 | 规格：25 mg | 目录价：￥540 |
| 货号：AG-CR1-3644-M100 | 规格：100 mg | 目录价：￥840 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Niclosamide . ethanolamine
别名:
Niclosamide-olamine; Clonitralide; Bayluscide; BAY-6076; HL2448; Mollutox; 2',5-Dichloro-4'-nitro-salicylanilide 2-aminoethanol salt
产品描述:
With slightly better solubility properties compared to Niclosamide (Prod. No. AG-CR1-3643). Antihelminthic, molluscicide and trypanocidal agent that inhibits mitochondrial oxidative phosphorylation and anaerobic ATP production. Anticancer agent with antiproliferative activity in a broad spectrum of cancer cells. Targets and inhibits multiple signaling pathways, including STAT3, NF-kB, Wnt/beta-catenin, Notch and mTORC1. Shown to block TNF-alpha-induced IkappaBalpha phosphorylation, translocation of p65 and the expression of NF-kappaB-regulated genes and elevates reactive oxygen species (ROS) levels. Promotes Frizzled1 internalization, down-regulates the expression of Dishevelled-2 protein and inhibits beta-catenin stabilization. Inhibits mTORC1 but not mTORC2 signaling in cells maintained in nutrient-rich conditions. Cell permeable selective STAT3 inhibitor (IC50=0.25µM). Inhibits the activation, nuclear translocation and transactivation of STAT3. Selective over STAT1, STAT5, JAK1, JAK2 and Src kinases. Induces cell cycle arrest, growth inhibition, autophagy and apoptosis. Inhibits S100A4 (Metastasin-1)-induced metastasis in vivo. Inhibits androgen receptor (AR) splice variants. Anti-inflammatory compound. Quorum sensing inhibitor. Broad-spectrum antiviral agent that targets acidified endosomes. Has been shown to inhibit replication of SARS and is a potential candidate to treat SARS-CoV-2 (COVID-19) infections. Antiobesity and antidiabetic agent. Positive allosteric neuropetide Y4 receptor ligand and increases energy expenditure and lipid metabolism through mitochondrial uncoupling.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
327.1 . 61.1
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98%
CAS号:
1420-04-8
分子式:
C13H8Cl2N2O4 . C2H7NO
溶解度:
Soluble in DMSO (30mg/ml), dimethylformamide or 100% ethanol. Sparingly soluble in water.
您可能感兴趣的产品
Engineered RNase Inhibitor, 60ug
货号：E-0075-006
SARS-CoV-2 Main Protease Inhibitor (GC376)
货号：701964
cGAS Inhibitor (CU-76)
货号：701934
FSP1 Inhibitor (iFSP1)
货号：701905
Sitagliptin Positive Control Inhibitor
货号：700214
AZ-PFKFB3-67
货号：43952-1 mg
DS9300
货号：43812-10 mg
Bifemelane (hydrochloride)
货号：43732-10 mg
促销活动
精品推荐
复制QQ号成功，请打开QQ后添加好友进行咨询