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折扣/货期| 货号：SIH-604-25MG | 规格：25 mg | 目录价：￥4248 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
NLRP3
别名:
N-[[(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-2-furansulfonamide sodium salt; CRID3; CP-456773 sodium salt
产品描述:
NLRP3 inflammasome activation inhibitor
保存温度:
-20ºC
运输温度:
Shipped Ambient
预期分子量:
426.5
产品形式:
White powder
产地:
加拿大
功能与背景:
NLRP3 (MCC950) was originally found to act as a cytokine release inhibitory drug (CRID), arresting activated monocytes and preventing activation of caspase-1(1). Discovered to be a novel inhibitor of the NLRP3 and AIM2 inflammasomes(2). Blocks canonical and noncanonical NLRP3 activation at nanomolar concentrations3. Inhibits interleukin 1β (IL-1β) secretion in vivo and attenuates the severity of experimental autoimmune encephalomyelitis (an MS disease model)(3). Disrupts the interaction between AIM2 and ASC in a reconstituted cell-free inflammasome(4). A valuable new tool for exploring the pathophysiology of NLRP3. It may contribute to additional alpha synuclein aggregation and cell loss in PD (5).
纯度:
>98% (HPLC); NMR (Conforms)
来源:
Synthetic
CAS号:
256373-96-3
分子式:
C20H23N2O5S ∙ Na
溶解度:
May be dissolved in water (30 mg/ml): or DMSO (40 mg/ml)
PubChem CID:
1234617
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