Nucleosome, Recombinant Human, Acidic Patch Mutant H2AE92K Biotinylated-突变/修饰核小体-深圳欣博盛生物科技有限公司

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Nucleosome, Recombinant Human, Acidic Patch Mutant H2AE92K Biotinylated

品牌：EpiCypher

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说明书

折扣/货期

货号：16-0030

规格：50 µg

目录价：￥5700

产品详情

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产品名称:

Nucleosome, Recombinant Human, Acidic Patch Mutant H2AE92K Biotinylated

产品描述:

Recombinant mononucleosomes consist of 147 base pairs of DNA wrapped around an octamer core of histone proteins (two each of H2A, H2B, H3.1, and H4) to form a nucleosome, the basic repeating unit of chromatin. The 147 bp 601 sequence containing a 5’ biotin-TEG group has high affinity for histone octamers and is useful for nucleosome assembly [1]. Histone H2A contains a glutamate-to-lysine (E-to-K) substitution at position 92 (H2AE92K). H2AE92 is among key residues forming a negatively charged region on the nucleosome surface named the “acidic patch”. The acidic patch is a conserved interaction hub for neighboring nucleosomes and nucleosome binding proteins, often via salt bridges with arginine anchors, and is functionally critical in chromatin condensation and chromatin remodeling [2-4]. H2AE92 resides in the H2A C-terminal extension and is associated with nucleosome binding factors such as histone H4 N-terminal tail, LANA, RCC1, IL-33, SIR3, HMGN2, and remodeling ATPases [2-4]. H2AE92K disrupts binding with SMARCB1 [5].

宿主来源:

Human

表达系统:

E. coli & synthetic DNA

保存温度:

Stable for six months at -80°C from date of receipt. For best results, aliquot and avoid freeze/thaws.

运输温度:

Dry ice.

产地:

美国

生产商:

EpiCypher