Nucleosome, Recombinant Human, Acidic Patch Mutant H2BE105A,E113A-突变/修饰核小体-深圳欣博盛生物科技有限公司

首页产品中心突变/修饰核小体

Nucleosome, Recombinant Human, Acidic Patch Mutant H2BE105A,E113A

品牌：EpiCypher

官网链接

说明书

折扣/货期

货号：16-1031

规格：50 µg

目录价：￥5700

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Nucleosome, Recombinant Human, Acidic Patch Mutant H2BE105A,E113A

产品描述:

Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B*, H3 and H4; accession numbers: H2A-P04908; H2B-O60814*; H3.1-P68431; H4-P62805) wrapped by 147 base pairs of 601 positioning sequence DNA [1]. *Histone H2B contains a glutamate-to-alanine (E-to-A) substitution at positions 105 and 113 (H2BE105A,E113A). H2BE105 and H2BE113 are among key residues forming a negatively charged region on the nucleosome surface named the “acidic patch”. The acidic patch is a conserved interaction hub for neighboring nucleosomes and nucleosome binding proteins, often via salt bridges with arginine anchors, and is functionally critical in chromatin condensation and chromatin remodeling [2-4]. H2B E105 and E113 both reside in the H2B alphaC extension and are associated with nucleosome binding factors such as histone H4 N-terminal tail, LANA, RCC1, HMGN2 and SMARCB1 [2,5].

保存温度:

Stable for six (6) months at -80°C from date of receipt. For best results, aliquot and avoid multiple freeze/thaws.

运输温度:

Dry ice.

产地:

美国

生产商:

EpiCypher

您可能感兴趣的产品

H3.3S31phos,K36me3 Recombinant Nucleosome, Biotinylated

货号：16-0407

H3T11phos Recombinant Nucleosome, Biotinylated