OAZ1 antibody, N-term-多抗-深圳欣博盛生物科技有限公司

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OAZ1 antibody, N-term

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX81427

规格：400μl

目录价：￥5600

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

OAZ1 antibody, N-term

别名:

ornithine decarboxylase antizyme 1 , AZ1 , AZI , OAZ

反应种属:

Human, Mouse

宿主来源:

Rabbit

实验应用:

IHC-P, WB

同种型:

IgG

免疫原:

KLH conjugated synthetic peptide between 2-31 amino acids from the N-terminal region of human OAZ1.

克隆性:

Polyclonal

克隆号:

纯化方式:

Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

偶联:

Unconjugated

产品浓度:

Batch dependent (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

产品形式:

Liquid

存储溶液:

PBS, 0.09% Sodium azide.

生产商:

GeneTex

功能与背景:

The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]

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