OSI-930-抑制剂-深圳欣博盛生物科技有限公司

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OSI-930

品牌：Cayman

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说明书

折扣/货期

货号：29379-10 mg	规格：10 mg	目录价：￥3069
货号：29379-25 mg	规格：25 mg	目录价：￥6767
货号：29379-5 mg	规格：5 mg	目录价：￥1621
货号：29379-50 mg	规格：50 mg	目录价：￥11980

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

OSI-930

产品描述:

A dual inhibitor of Kit (IC50s = 80 and 629 nM for the actived and non-activated kinase, respectively, in cell-free assays) and the kinase insert domain receptor (KDR; IC50 = 9 nM); selective for these kinases over a panel of 13 additional kinases (IC50s = 1.3->10 µM) but also inhibits FLT1, CSF1R, C-RAF, and LCK (IC50s = 8, 15, 41, and 22 nM, respectively); inhibits Kit autophosphorylation in NCI-H526 and HMC-1 cells expressing wild-type Kit and Kit containing the constitutively active KitV560G mutation, respectively, and stem cell factor-induced Kit autophosphorylation in NCI-H526 cells expressing wild-type Kit (IC50s = 58.1 and 78.9 nM, respectively); inhibits VEGF-induced autophosphorylation of VEGFR2 in HUVECs (IC50 = 64.4 nM); decreases endothelial sprout formation by >50% in isolated rat aortic rings at 100 nM; reduces tumor growth in a variety of mouse xenograft models at 200 mg/kg per day

保存温度:

-20

运输温度:

-20

预期分子量:

443.442669

产品形式:

A crystalline solid

纯度:

≥98%

CAS号:

728033-96-3