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折扣/货期| 货号：GTX05259 | 规格：6ml | 目录价：￥5600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
P16 antibody [JC2] (ready-to-use)
别名:
ARF,CDK4I,CDKN2,CDKN2A,CMM2,INK4,INK4A,MLM,MTS1,P14,P14ARF,P16,P16INK4,P16INK4A,P19,P19ARF,TP16,cyclin dependent kinase inhibitor 2A,p16,p16INK4a,p14ARF,p19ARF,P14 ARF,p19 ARF
反应种属:
Human
宿主来源:
Mouse
实验应用:
IHC-P
同种型:
IgG2a
免疫原:
Recombinant prokaryotic full length human P16 INK4 protein
克隆性:
Monoclonal
克隆号:
JC2
纯化方式:
Unpurified
偶联:
Unconjugated
产品浓度:
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. Store at 4ºC. DO NOT FREEZE.
运输温度:
4°C
预期分子量:
17
产品形式:
Liquid
存储溶液:
Tissue culture supernatant, 0.09% Sodium azide.
生产商:
GeneTex
功能与背景:
This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene; this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, the E3 ubiquitin-protein ligase MDM2, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene. [provided by RefSeq, Sep 2012]
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