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折扣/货期| 货号：GTX642296 | 规格：100μg | 目录价：￥6500 |
| 货号：GTX642296-S | 规格：100μl | 目录价：￥3300 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
p27 Kip1 antibody [HMV3970] HistoMAX™
别名:
C-C motif chemokine ligand 2 , GDCF-2 , HC11 , HSMCR30 , MCAF , MCP-1 , MCP1 , SCYA2 , SMC-CF
反应种属:
Human
宿主来源:
Mouse
实验应用:
Neutralizing/Inhibition, WB
靶标/特异性:
The antibody will neutralize the biological activity of recombinant human MCP-1.This antibody does not exhibit cross-reactivity with recombinant human RANTES, recombinant human MIP-1α, or recombinant mouse MIP-1α..
同种型:
IgG1
免疫原:
recombinant human MCP-1/CCL2 expressed in E. coli.
克隆性:
Monoclonal
克隆号:
24822
纯化方式:
Purified immunoglobulin
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
11
产品形式:
Liquid
存储溶液:
PBS carbohydrates, no preservatives.
生产商:
GeneTex
功能与背景:
Monocyte chemotactic protein (MCP1) is also known as monocyte chemotactic and activating factor (MCAF). It is the product of the human JE gene. The precursor form of MCP1 consists of 99 amino acids with a signal peptide sequence consisting of 23 amino-terminal acids. The mature form of MCP1 has 4 cysteine residues. The first two cysteine residues are in an adjacent position C-C, which characterizes MCP1 as a member of the chemokine beta subfamily. rhMCP1 is a non-glycosylated protein consisting of 76 amino acids with a molecular weight of 8.7 kDa. MCP1 mRNA expression can be induced in monocytes/macrophages, B lymphocytes, endothelial cells and astrocytoma cells by LPS. IL1 will induce production of MCP1 in fibroblasts, keratinocytes, hepatoma cells and Type II pneumocytes. In vitro, MCP1 will act on monocytes to initiate chemotaxis, induce superoxide anion release, induce the release of lysosomal enzymes, and augment cytostatic activity. In vivo, MCP1 will induce macrophage infiltration. The MCP1 gene contains potential binding sites for several transcription factors, including AP1, AP2, NFkB, and NFIL6.
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