PALB2 antibody-多抗-深圳欣博盛生物科技有限公司

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PALB2 antibody

品牌：GeneTex

官网链接

说明书

折扣/货期

货号：GTX85263

规格：100μg

目录价：￥6200

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

PALB2 antibody

别名:

partner and localizer of BRCA2 , FANCN , PNCA3

反应种属:

Human, Mouse, Rat

宿主来源:

Rabbit

实验应用:

ELISA, WB

靶标/特异性:

At least four isoforms of PALB2 are known to exist; this antibody will detect all four isoforms.

同种型:

IgG

免疫原:

PALB2 antibody was raised against a 15 amino acid synthetic peptide from near the carboxy terminus of human PALB2.The immunogen is located within amino acids 940 - 990 of PALB2.

克隆性:

Polyclonal

克隆号:

纯化方式:

Purified by antigen-affinity chromatography

偶联:

Unconjugated

产品浓度:

1 mg/ml (Please refer to the vial label for the specific concentration.)

保存温度:

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

运输温度:

4°C

预期分子量:

131

产品形式:

Liquid

存储溶液:

PBS, 0.02% Sodium azide.

生产商:

GeneTex

功能与背景:

The breast cancer early onset proteins BRCA1 and BRCA2 are central to the repair of DNA damage by homologous recombination and are strongly associated with inherited breast and ovarian cancer. The protein PALB2 is required for the localization of BRCA2 to sites of DNA damage and like BRCA1 and 2 is a breast cancer susceptibility gene. PALB2 is thought to function through directly binding to BRCA1, which allows the PALB2 protein to organize BRCA2 and the recombinase RAD51 at the site of DNA damage. Analysis of the BRCA1-PALB2-BRCA2-RAD51network may allow predictions to be made of the responsiveness of a particular tumor to therapeutic treatments. At least four isoforms of PALB2 are known to exist.

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