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折扣/货期| 货号：25-473 | 规格：100 ul | 目录价：￥9108.45 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PATZ1 Antibody
别名:
PATZ1, MAZR, PATZ, RIAZ, ZBTB19, ZNF278, ZSG, dJ400N23
反应种属:
Human,Mouse,Rat
宿主来源:
Rabbit
实验应用:
ELISA,WB
克隆性:
Polyclonal
纯化方式:
Antibody is purified by peptide affinity chromatography method.
偶联:
Unconjugated
产品浓度:
batch dependent
保存温度:
For short periods of storage (days) store at 4˚C. For longer periods of storage, store PATZ1 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
运输温度:
Blue Ice
产品形式:
Liquid
存储溶液:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
产地:
美国
生产商:
Prosci
功能与背景:
PATZ1 contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t (1;22) (p36.1;q12).The protein encoded by this gene contains an A-T hook DNA binding motif which usually binds to other DNA binding structures to play an important role in chromatin modeling and transcription regulation. Its Poz domain is thought to function as a site for protein-protein interaction and is required for transcriptional repression, and the zinc-fingers comprise the DNA binding domain. Since the encoded protein has typical features of a transcription factor, it is postulated to be a repressor of gene expression. In small round cell sarcoma, this gene is fused to EWS by a small inversion of 22q, then the hybrid is thought to be translocated (t (1;22) (p36.1;q12). The rearrangement of chromosome 22 involves intron 8 of EWS and exon 1 of this gene creating a chimeric sequence containing the transactivation domain of EWS fused to zinc finger domain of this protein. This is a distinct example of an intra-chromosomal rearrangement of chromosome 22. Four alternatively spliced transcript variants are described for this gene.
Accession #:
NP_055138
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