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折扣/货期| 货号：GTX10848 | 规格：25μg | 目录价：￥6600 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PDGF Receptor beta antibody
别名:
platelet derived growth factor receptor beta , CD140B , IBGC4 , IMF1 , JTK12 , KOGS , PDGFR , PDGFR-1 , PDGFR1 , PENTT
反应种属:
Human
宿主来源:
Goat
实验应用:
ELISA, FCM, IHC, IHC-P, Neutralizing/Inhibition, WB
靶标/特异性:
The antibody will neutralize soluble PDGF Rβ mediated bioactivity. It shows less than 1% cross-reactivity with recombinant human PDGF sRα.
同种型:
IgG
免疫原:
recombinant human soluble PDGF receptor β (PDGF Rβ) extracellular domain, expressed in NSO cells.
克隆性:
Polyclonal
克隆号:
纯化方式:
Purified by affinity chromatography
偶联:
Unconjugated
产品浓度:
Batch dependent (Please refer to the vial label for the specific concentration.)
保存温度:
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
运输温度:
4°C
预期分子量:
124
产品形式:
Liquid
存储溶液:
PBS, 5% Trehalose, no preservatives.
生产商:
GeneTex
功能与背景:
Platelet derived growth factor (PDGF), the major mitogen in serum for cultured connective tissue cells, exerts it actions via specific receptors on the cell surface. Two distinct human PDGF receptor transmembrane binding proteins have been identified, a 170 kDa, 1066 amino acid residue alpha-receptor (PDGF Ralpha) and a 190 kDa, 1074 amino acid residue beta-receptor (PDGF Rbeta). The two receptor proteins are structurally related and consist of an extracellular portion containing five immunoglobulin-like domains, a single transmembrane region, and an intracellular portion with a protein-tyrosine kinase domain. Ligand binding induces receptor dimerization and autophosphorylation, allowing binding and activation of cytoplasmic SH2-domain containing signal transduction molecules. Thereby, a number of different signaling pathways are initiated leading to cell growth, actin reorganization, migration and differentiation. Recent observations suggest that extensive cross-talk occurs between different signaling pathways, and that stimulatory signals are modulated by inhibitory signals arising in parallel. Between the two PDGF receptors, there is 44% overall sequence identity. Within the extracellular domain, 30% of the amino acid residues are identical. The different isoforms of PDGF (PDGF-AA, PDGF-AB and PDGF-BB) bind with different affinities to two distinct receptors. Ligand-binding induces receptor dimerization; the A-subunit of PDGF binds to alpha-receptors, whereas the B-subunit binds to both alpha- and beta-receptors. Binding of PDGF to its receptor activates the tyrosine kinase domain and leads to enhanced phosphorylation of intracellular substrates as well as to autophosphorylation of the receptor itself. In addition, several other cellular responses are induced. Studies have indicated that PDGF beta-receptors are not present on most cells of normal tissues, but are upregulated, in conjunction with inflammation, excess cell proliferation, malignancytic, and fibrotic conditions.
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