官网链接
折扣/货期| 货号：FY13345 | 规格：100 ul | 目录价：￥6488.05 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Phospho-GLUT4 (Ser488) Antibody / SLC2A4
产品描述:
Phospho-GLUT4 (Ser488) antibody detects GLUT4 phosphorylated at serine 488, encoded by the SLC2A4 gene. GLUT4 is an insulin responsive glucose transporter that regulates cellular glucose uptake, particularly in adipose tissue and skeletal muscle. Phospho-GLUT4 (Ser488) antibody provides researchers with a highly specific reagent to study glucose transport regulation, insulin signaling, and metabolic disease.
GLUT4 is stored in intracellular vesicles under basal conditions and translocates to the plasma membrane in response to insulin stimulation. Research using Phospho-GLUT4 (Ser488) antibody has shown that phosphorylation at Ser488 modulates GLUT4 trafficking and activity, influencing how cells respond to hormonal signals. This modification connects insulin receptor activation with downstream control of glucose uptake.
Studies with Phospho-GLUT4 (Ser488) antibody have revealed that phosphorylation at Ser488 is mediated by kinases activated during insulin signaling, including Akt and related pathways. This modification fine tunes the balance between vesicular storage and surface localization, ensuring that glucose uptake matches metabolic demands. Dysregulation of GLUT4 phosphorylation impairs glucose handling and contributes to insulin resistance.
In type 2 diabetes and obesity, abnormal GLUT4 trafficking is a hallmark feature. Research using Phospho-GLUT4 (Ser488) antibody has demonstrated that altered phosphorylation disrupts GLUT4 translocation, leading to reduced glucose uptake in muscle and adipose tissue. This impairment contributes directly to hyperglycemia and metabolic imbalance. Targeting GLUT4 phosphorylation is being investigated as a strategy to restore glucose homeostasis in diabetes therapy.
Phospho-GLUT4 (Ser488) antibody is widely applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting distinguishes phosphorylated from total GLUT4 protein, immunohistochemistry localizes activated transporter in tissue sections, and immunofluorescence reveals dynamic trafficking patterns in cells. These applications make the antibody indispensable for metabolic research.
By providing validated Phospho-GLUT4 (Ser488) antibody reagents, NSJ Bioreagents supports studies into insulin signaling, glucose transport, and metabolic disorders. Detection of GLUT4 phosphorylated at Ser488 provides insight into how cells regulate nutrient uptake under physiological and pathological conditions.
GLUT4 is stored in intracellular vesicles under basal conditions and translocates to the plasma membrane in response to insulin stimulation. Research using Phospho-GLUT4 (Ser488) antibody has shown that phosphorylation at Ser488 modulates GLUT4 trafficking and activity, influencing how cells respond to hormonal signals. This modification connects insulin receptor activation with downstream control of glucose uptake.
Studies with Phospho-GLUT4 (Ser488) antibody have revealed that phosphorylation at Ser488 is mediated by kinases activated during insulin signaling, including Akt and related pathways. This modification fine tunes the balance between vesicular storage and surface localization, ensuring that glucose uptake matches metabolic demands. Dysregulation of GLUT4 phosphorylation impairs glucose handling and contributes to insulin resistance.
In type 2 diabetes and obesity, abnormal GLUT4 trafficking is a hallmark feature. Research using Phospho-GLUT4 (Ser488) antibody has demonstrated that altered phosphorylation disrupts GLUT4 translocation, leading to reduced glucose uptake in muscle and adipose tissue. This impairment contributes directly to hyperglycemia and metabolic imbalance. Targeting GLUT4 phosphorylation is being investigated as a strategy to restore glucose homeostasis in diabetes therapy.
Phospho-GLUT4 (Ser488) antibody is widely applied in western blotting, immunohistochemistry, and immunofluorescence. Western blotting distinguishes phosphorylated from total GLUT4 protein, immunohistochemistry localizes activated transporter in tissue sections, and immunofluorescence reveals dynamic trafficking patterns in cells. These applications make the antibody indispensable for metabolic research.
By providing validated Phospho-GLUT4 (Ser488) antibody reagents, NSJ Bioreagents supports studies into insulin signaling, glucose transport, and metabolic disorders. Detection of GLUT4 phosphorylated at Ser488 provides insight into how cells regulate nutrient uptake under physiological and pathological conditions.
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
WB
同种型:
Rabbit IgG
免疫原:
A synthesized peptide derived from human Phospho-GLUT4 (S488) was used as the immunogen for the Phospho-GLUT4 (Ser488) antibody.
克隆性:
Recombinant Rabbit Monoclonal
克隆号:
32S34
纯化方式:
Affinity chromatography
保存温度:
Store the Phospho-GLUT4 (Ser488) antibody at -20oC.
产品形式:
Liquid
存储溶液:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA
产地:
美国
促销活动
复制QQ号成功，请打开QQ后添加好友进行咨询