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折扣/货期| 货号：FY12025 | 规格：100 ul | 目录价：￥6488 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Phospho-Tau (Ser199) Antibody / MAPT
产品描述:
Phospho-Tau (Ser199) antibody recognizes tau protein (MAPT) when phosphorylated at serine 199, a modification associated with neurodegenerative disease. Tau is a microtubule-associated protein that stabilizes cytoskeletal structure in neurons. In Alzheimer's disease and related tauopathies, abnormal phosphorylation of tau at multiple sites, including Ser199, leads to microtubule destabilization and the formation of neurofibrillary tangles.
Research employing Phospho-Tau (Ser199) antibody has shown that phosphorylation at this site correlates with early pathological changes in Alzheimer's models. Ser199 phosphorylation is regulated by kinases such as GSK-3beta and CDK5, linking tau pathology to altered kinase activity. Monitoring this specific phosphorylation event provides valuable insight into mechanisms of neuronal dysfunction and progression of tau-related diseases.
Antibodies directed against phospho-tau (Ser199) are validated for applications including western blot, immunofluorescence, and immunohistochemistry. They allow researchers to discriminate between total tau and phosphorylated tau, supporting studies of disease biomarkers, kinase regulation, and therapeutic intervention strategies. Clone validation ensures specificity for the phosphorylated residue, avoiding cross-reactivity with non-modified tau.
NSJ Bioreagents offers this Phospho-Tau (Ser199) antibody to support investigations into Alzheimer's disease, tauopathies, and neuronal cytoskeletal regulation. Alternate names include MAPT antibody, microtubule-associated protein tau antibody, and paired helical filament antibody.
Research employing Phospho-Tau (Ser199) antibody has shown that phosphorylation at this site correlates with early pathological changes in Alzheimer's models. Ser199 phosphorylation is regulated by kinases such as GSK-3beta and CDK5, linking tau pathology to altered kinase activity. Monitoring this specific phosphorylation event provides valuable insight into mechanisms of neuronal dysfunction and progression of tau-related diseases.
Antibodies directed against phospho-tau (Ser199) are validated for applications including western blot, immunofluorescence, and immunohistochemistry. They allow researchers to discriminate between total tau and phosphorylated tau, supporting studies of disease biomarkers, kinase regulation, and therapeutic intervention strategies. Clone validation ensures specificity for the phosphorylated residue, avoiding cross-reactivity with non-modified tau.
NSJ Bioreagents offers this Phospho-Tau (Ser199) antibody to support investigations into Alzheimer's disease, tauopathies, and neuronal cytoskeletal regulation. Alternate names include MAPT antibody, microtubule-associated protein tau antibody, and paired helical filament antibody.
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
WB
同种型:
Rabbit IgG
免疫原:
A synthesized peptide derived from human Phospho-Tau (S199) was used as the immunogen for the Phospho-Tau (Ser199) antibody.
克隆性:
Recombinant Rabbit Monoclonal
克隆号:
31M19
纯化方式:
Affinity-chromatography
保存温度:
Store the Phospho-Tau (Ser199) antibody at -20oC.
产品形式:
Liquid
存储溶液:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA
产地:
美国
促销活动
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