深圳欣博盛生物科技有限公司

Histone H3 (acetyl K14) Antibody / HIST1H3A

Histone H3 (acetyl K14) antibody detects Histone H3 acetylated at lysine 14, encoded by the HIST1H3A gene. Histone H3 is a core component of the nucleosome, the fundamental unit of chromatin structure, and acetylation at lysine 14 is a key epigenetic modification that regulates gene expression. Histone H3 (acetyl K14) antibody provides researchers with a specific reagent for studying histone acetylation, chromatin remodeling, and transcriptional control.

Histone H3 is one of the four canonical histones, which assemble into octamers with two copies each of H2A, H2B, H3, and H4. Research using Histone H3 (acetyl K14) antibody has shown that acetylation at lysine 14 is catalyzed by histone acetyltransferases such as GCN5 and PCAF. This modification neutralizes positive charges on histone tails, loosening chromatin structure and facilitating access of transcriptional machinery.

Studies with Histone H3 (acetyl K14) antibody have revealed that this acetylation mark is associated with active gene promoters and enhancers. It serves as a recognition site for bromodomain proteins that recruit transcription factors and co-activators, driving gene activation. This highlights the central role of K14 acetylation in epigenetic regulation.

Dysregulation of histone acetylation, including acetylation at lysine 14, is linked to cancer and developmental disorders. Research using Histone H3 (acetyl K14) antibody has shown that aberrant acetylation patterns are associated with oncogene activation and tumor suppressor silencing. Therapeutic strategies that target histone acetyltransferases and deacetylases are being investigated to restore balanced histone acetylation in disease contexts.

Histone H3 (acetyl K14) antibody is widely used in chromatin immunoprecipitation, western blotting, and immunofluorescence. Chromatin immunoprecipitation maps genome-wide localization of acetylated H3, western blotting quantifies modification levels, and immunofluorescence reveals nuclear distribution in different cell states. These approaches make Histone H3 (acetyl K14) antibody indispensable for epigenetics research.

By providing validated Histone H3 (acetyl K14) antibody reagents, NSJ Bioreagents supports studies into chromatin remodeling, epigenetics, and transcriptional regulation. Detection of Histone H3 acetylated at lysine 14 provides researchers with insight into how histone modifications control gene expression.

Human, Mouse, Rat

Rabbit

WB, IHC, ICC, IF, IP

Rabbit IgG

A synthesized peptide derived from human Histone H3 (acetyl K14) was used as the immunogen for the Histone H3 (acetyl K14) antibody.

Recombinant Rabbit Monoclonal

BID-8

Affinity-chromatography

Store the Histone H3 (acetyl K14) antibody at -20oC.

Liquid

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA

美国