官网链接
折扣/货期| 货号：FY13349 | 规格：100 ul | 目录价：￥6488.05 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Phospho-Tau (Ser202) Antibody / MAPT
产品描述:
Phospho-Tau (Ser202) antibody detects Tau protein phosphorylated at serine 202, encoded by the MAPT gene. Tau is a microtubule associated protein that stabilizes neuronal microtubules and regulates axonal transport. Phospho-Tau (Ser202) antibody provides researchers with a critical reagent to study neurodegeneration, Alzheimer disease, and tauopathies associated with abnormal Tau phosphorylation.
Tau normally binds and stabilizes microtubules in axons, promoting neuronal structure and intracellular transport. Research using Phospho-Tau (Ser202) antibody has shown that phosphorylation at Ser202 reduces Tau binding to microtubules, leading to destabilization and cytoskeletal disorganization. This modification is an early hallmark of pathological Tau in Alzheimer disease.
Studies with Phospho-Tau (Ser202) antibody have revealed that hyperphosphorylation at Ser202 and neighboring residues contributes to Tau aggregation into neurofibrillary tangles. These aggregates impair neuronal function and survival, driving neurodegeneration. Detection of Ser202 phosphorylation therefore provides an important marker for disease progression in tauopathies.
In Alzheimer disease, Phospho-Tau (Ser202) antibody has demonstrated strong immunoreactivity in affected brain regions such as the hippocampus and cortex. This phosphorylation is mediated by kinases including GSK3 beta and CDK5, linking Tau pathology to signaling pathways dysregulated in disease. Monitoring Ser202 phosphorylation offers insight into how signaling cascades contribute to neuronal dysfunction.
Beyond Alzheimer disease, Tau phosphorylation at Ser202 is implicated in other neurodegenerative conditions such as progressive supranuclear palsy, corticobasal degeneration, and frontotemporal dementia. Research using Phospho-Tau (Ser202) antibody has shown that this site is consistently phosphorylated across tauopathies, making it a reliable disease marker.
Phospho-Tau (Ser202) antibody is widely used in immunohistochemistry, western blotting, and immunofluorescence. Immunohistochemistry highlights phosphorylated Tau aggregates in brain tissue, western blotting distinguishes pathological from normal isoforms, and immunofluorescence demonstrates subcellular accumulation in neurons. These approaches make the antibody essential for neurodegeneration research.
By supplying validated Phospho-Tau (Ser202) antibody reagents, NSJ Bioreagents supports studies into Alzheimer disease, tauopathies, and neuronal dysfunction. Detection of Tau phosphorylated at Ser202 provides insight into the molecular events driving neurodegeneration.
Tau normally binds and stabilizes microtubules in axons, promoting neuronal structure and intracellular transport. Research using Phospho-Tau (Ser202) antibody has shown that phosphorylation at Ser202 reduces Tau binding to microtubules, leading to destabilization and cytoskeletal disorganization. This modification is an early hallmark of pathological Tau in Alzheimer disease.
Studies with Phospho-Tau (Ser202) antibody have revealed that hyperphosphorylation at Ser202 and neighboring residues contributes to Tau aggregation into neurofibrillary tangles. These aggregates impair neuronal function and survival, driving neurodegeneration. Detection of Ser202 phosphorylation therefore provides an important marker for disease progression in tauopathies.
In Alzheimer disease, Phospho-Tau (Ser202) antibody has demonstrated strong immunoreactivity in affected brain regions such as the hippocampus and cortex. This phosphorylation is mediated by kinases including GSK3 beta and CDK5, linking Tau pathology to signaling pathways dysregulated in disease. Monitoring Ser202 phosphorylation offers insight into how signaling cascades contribute to neuronal dysfunction.
Beyond Alzheimer disease, Tau phosphorylation at Ser202 is implicated in other neurodegenerative conditions such as progressive supranuclear palsy, corticobasal degeneration, and frontotemporal dementia. Research using Phospho-Tau (Ser202) antibody has shown that this site is consistently phosphorylated across tauopathies, making it a reliable disease marker.
Phospho-Tau (Ser202) antibody is widely used in immunohistochemistry, western blotting, and immunofluorescence. Immunohistochemistry highlights phosphorylated Tau aggregates in brain tissue, western blotting distinguishes pathological from normal isoforms, and immunofluorescence demonstrates subcellular accumulation in neurons. These approaches make the antibody essential for neurodegeneration research.
By supplying validated Phospho-Tau (Ser202) antibody reagents, NSJ Bioreagents supports studies into Alzheimer disease, tauopathies, and neuronal dysfunction. Detection of Tau phosphorylated at Ser202 provides insight into the molecular events driving neurodegeneration.
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
WB
同种型:
Rabbit IgG
免疫原:
A synthesized peptide derived from human Phospho-Tau (S202) was used as the immunogen for the Phospho-Tau (Ser202) antibody.
克隆性:
Recombinant Rabbit Monoclonal
克隆号:
31M22
纯化方式:
Affinity chromatography
保存温度:
Store the Phospho-Tau (Ser202) antibody at -20oC.
产品形式:
Liquid
存储溶液:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA
产地:
美国
促销活动
复制QQ号成功，请打开QQ后添加好友进行咨询