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折扣/货期| 货号：FY12011 | 规格：100 ul | 目录价：￥6488.05 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Phospho-UBF1 (Ser484) Antibody / Upstream-binding factor 1
产品描述:
Phospho-UBF1 (Ser484) antibody recognizes upstream binding factor 1 phosphorylated at serine 484, a modification critical for ribosomal RNA transcription. UBF1 is a nucleolar transcription factor that binds rDNA promoters and recruits RNA polymerase I machinery to initiate rRNA synthesis. Phosphorylation at Ser484 is mediated by signaling kinases such as ERK and enhances UBF1 activity, thereby linking growth factor signaling to ribosome biogenesis.
Research employing Phospho-UBF1 (Ser484) antibody has highlighted its role in cell growth and proliferation. Enhanced UBF1 phosphorylation correlates with increased ribosome production in rapidly dividing cells, including cancer cells, where heightened protein synthesis supports tumor growth. Conversely, reduced phosphorylation is associated with decreased rRNA transcription during cellular stress or growth arrest, making Ser484 phosphorylation a sensitive marker of nucleolar activity.
Antibodies specific for phospho-UBF1 at Ser484 are useful in assays such as western blot, immunofluorescence, and chromatin immunoprecipitation. These reagents allow researchers to study how signaling pathways regulate ribosome synthesis and how nucleolar activity adapts to physiological conditions. Clone-based validation ensures that detection is specific to the phosphorylated form rather than total UBF1.
NSJ Bioreagents offers this Phospho-UBF1 (Ser484) antibody to aid in research on transcriptional regulation, signal transduction, and cancer biology. Alternate names include upstream binding factor 1 antibody, nucleolar transcription factor 1 antibody, and NOR-90 antibody.
Research employing Phospho-UBF1 (Ser484) antibody has highlighted its role in cell growth and proliferation. Enhanced UBF1 phosphorylation correlates with increased ribosome production in rapidly dividing cells, including cancer cells, where heightened protein synthesis supports tumor growth. Conversely, reduced phosphorylation is associated with decreased rRNA transcription during cellular stress or growth arrest, making Ser484 phosphorylation a sensitive marker of nucleolar activity.
Antibodies specific for phospho-UBF1 at Ser484 are useful in assays such as western blot, immunofluorescence, and chromatin immunoprecipitation. These reagents allow researchers to study how signaling pathways regulate ribosome synthesis and how nucleolar activity adapts to physiological conditions. Clone-based validation ensures that detection is specific to the phosphorylated form rather than total UBF1.
NSJ Bioreagents offers this Phospho-UBF1 (Ser484) antibody to aid in research on transcriptional regulation, signal transduction, and cancer biology. Alternate names include upstream binding factor 1 antibody, nucleolar transcription factor 1 antibody, and NOR-90 antibody.
反应种属:
Human, Mouse, Rat
宿主来源:
Rabbit
实验应用:
WB, IHC
同种型:
Rabbit IgG
免疫原:
A synthesized peptide derived from human Phospho-UBF1 (S484) was used as the immunogen for the Phospho-UBF1 (Ser484) antibody.
克隆性:
Recombinant Rabbit Monoclonal
克隆号:
32U21
纯化方式:
Affinity-chromatography
保存温度:
Store the Phospho-UBF1 (Ser484) antibody at -20oC.
产品形式:
Liquid
存储溶液:
Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.
产地:
美国
上一个:BCL2L15 Antibody / BCL2 like protein 15
下一个:UFC1 Antibody / Ubiquitin-fold modifier conjugating enzyme 1
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