PKR Antibody-多抗-深圳欣博盛生物科技有限公司

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PKR Antibody

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：F40174-0.08ML	规格：0.08 ml	目录价：￥2962.25
货号：F40174-0.4ML	规格：0.4 ml	目录价：￥6343.55

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

PKR Antibody

产品描述:

Interferon-induced, double-stranded RNA-activated protein kinase (PRKR/PKR) is a serine-threonine kinase. Activation by dsRNAs leads to autophosphorylation of PKR and allows the kinase to phosphorylate its natural substrate, the alpha subunit of eukaryotic protein synthesis initiation factor-2 (EIF2-alpha), leading to the inhibition of protein synthesis. PRKR, which is involved in TLR signaling and mediates apoptosis in fibroblasts in response to viral infection and inflammatory cytokines, activates IKK and NFKB, thereby suppressing apoptosis. Apoptosis induced by live pathogenic gram-positive and gram-negative bacteria requirs both TLR4 and PKR, possibly representing a major mechanism for pathogenic bacteria that use specific virulence factors to avoid detection and destruction by the innate immune system.

反应种属:

Human, Mouse

宿主来源:

Rabbit

实验应用:

WB, IHC, ELISA

同种型:

Rabbit Ig

免疫原:

A portion of amino acids 11-42 from the human protein was used as the immunogen for this PKR antibody.

克隆性:

Polyclonal (rabbit origin)