PRKR Antibody-多抗-深圳欣博盛生物科技有限公司

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PRKR Antibody

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：F40175-0.08ML	规格：0.08 ml	目录价：￥2962.25
货号：F40175-0.4ML	规格：0.4 ml	目录价：￥6343.55

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

PRKR Antibody

产品描述:

Interferon-induced, double-stranded RNA-activated protein kinase is a serine-threonine kinase. Activation by dsRNAs leads to autophosphorylation of PRKR and allows the kinase to phosphorylate its natural substrate, the alpha subunit of eukaryotic protein synthesis initiation factor-2 (EIF2-alpha), leading to the inhibition of protein synthesis. Human gamma-interferon (IFNG) mRNA exploits localized activation of PRKR in the cell to regulate its own translation. IFNG mRNA activates PRKR through a pseudoknot in its 5-prime untranslated region. The HCV envelope protein E2 contains a sequence identical with phosphorylation sites of the interferon-inducible protein kinase PRKR and the translation initiation factor EIF2-alpha, a target of PRKR. E2 inhibits the kinase activity of PRKR and blocks its inhibitory effect on protein synthesis and cell growth, which provides one mechanism by which HCV may circumvent the antiviral effect of interferon.

反应种属:

Human, Mouse

宿主来源:

Rabbit

实验应用:

WB, IHC, ELISA

同种型:

Rabbit Ig

免疫原:

A portion of amino acids 519-550 from the human protein was used as the immunogen for this PRKR antibody.

克隆性:

Polyclonal (rabbit origin)