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折扣/货期| 货号：18012-10 mg | 规格：10 mg | 目录价：￥2720 |
| 货号：18012-25 mg | 规格：25 mg | 目录价：￥6392 |
| 货号：18012-5 mg | 规格：5 mg | 目录价：￥1434 |
| 货号：18012-50 mg | 规格：50 mg | 目录价：￥11323 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
PLX647
产品描述:
A dual inhibitor of FMS and KIT (IC50s = 28 and 16 nM, respectively); is selective for FMS and KIT but does inhibit FLT3 and KDR (IC50s = 91 and 130 nM, respectively) in a panel of 400 kinases at 1 μM; inhibits proliferation of Ba/F3 cells expressing constitutively active FMS or KIT (IC50s = 92 and 180 nM, respectively) as well as ligand-dependent growth of M-NFS-60 and M-07e cells (IC50s = 380 and 230 nM, respectively); reduces TNF-α and IL-6 release in a rat model of LPS-induced cytokine release at 40 mg/kg; reduces mast cell degranulation in a mouse model of PCA; inhibits bone destruction and delays disease progression in a mouse model of CIA; reverses bone osteolysis and allodynia in a syngeneic rat model of cancer-induced bone pain
保存温度:
-20
运输温度:
-20
预期分子量:
382.4
产品形式:
A crystalline solid
纯度:
≥95%
CAS号:
873786-09-5
分子式:
C21H17F3N4
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