PMS1 Antibody / PMS1 protein homolog 1-单抗-深圳欣博盛生物科技有限公司

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PMS1 Antibody / PMS1 protein homolog 1

品牌：NSJ Bio

官网链接

说明书

折扣/货期

货号：V9715SAF-100UG

规格：100 ug

目录价：￥6414.1

产品详情

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产品名称:

PMS1 Antibody / PMS1 protein homolog 1

产品描述:

The finding that mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) has resulted in considerable interest in the understanding of the mechanism of DNA mismatch repair. Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were demonstrated at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression. Two additional homologs of the prokaryotic MutL gene, designated PMS1 and PMS2, have been identified and shown to be mutated in the germline of HNPCC patients.

反应种属:

Human

宿主来源:

Mouse

实验应用:

ELISA, FACS, IF

同种型:

Mouse IgG1

免疫原:

Recombinant full-length human PMS1 protein was used as the immunogen for the PMS1 antibody.

克隆性:

Monoclonal (mouse origin)