POLR2A Antibody / RNA polymerase II subunit RPB1-单抗-深圳欣博盛生物科技有限公司

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POLR2A Antibody / RNA polymerase II subunit RPB1

品牌：NSJ Bio

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说明书

折扣/货期

货号：V7452-100UG	规格：100 ug	目录价：￥6652.1
货号：V7452-20UG	规格：20 ug	目录价：￥3082.1

产品详情

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产品名称:

POLR2A Antibody / RNA polymerase II subunit RPB1

产品描述:

RNA polymerase II (Pol II) is an enzyme that is composed of 12 subunits and is responsible for the transcription of protein-coding genes. Transcription initiation requires Pol II-mediated recruitment of transcription machinery to a target promoter, thereby allowing transcription to begin. The largest subunit of Pol II (referred to as RPB1 or RPB205) is a 1,840 amino acid protein that contains one C2H2-type zinc finger and a C-terminal domain comprised of several heptapeptide repeats. Although Pol II function requires the cooperation of all twelve subunits, the largest subunit conveys Pol II catalytic activity and, together with the second largest subunit, forms the active center of the Pol II enzyme. Additionally, the large subunit participates in forming the DNA-binding domain of Pol II, a groove that is necessary for transcription of the DNA template. Without proper function of the large subunit, mRNA synthesis and subsequent transcription elongation cannot occur.

反应种属:

Human, Mouse, Rat

宿主来源:

Mouse

实验应用:

FACS, IF, WB, IHC-P

同种型:

Mouse IgG1, kappa

免疫原:

The immunogen for this POLR2A antibody was 10 repeats of synthetic peptide YSPTSPS using chemically synthesized phospho-S5.

克隆性:

Monoclonal (mouse origin)