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折扣/货期| 货号：11494-1 mg | 规格：1 mg | 目录价：￥429 |
| 货号：11494-10 mg | 规格：10 mg | 目录价：￥1461 |
| 货号：11494-5 mg | 规格：5 mg | 目录价：￥1152 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
Ponatinib
别名:
AP 24534
产品描述:
A multi-kinase inhibitor; inhibits Bcr-Abl, Bcr-AblT315I, and various other Bcr-Abl mutants (IC50s = 0.37, 2, and 0.3-0.44 nM, respectively); selective for Bcr-Abl and these mutants over the insulin receptor, IGF-1R, Aurora A kinase, and Cdk2/cyclin E (IC50s = >1,000 nM for all) but does inhibit c-Src, VEGFR2, FGFR1, and PDGFRα (IC50s = 5.4, 1.5, 2.2, and 1.1 nM, respectively); inhibits RIPK2 (IC50 = 6.7 nM) and NF-κB activation in vitro; inhibits NLRP3 inflammasome activation in BMDMs; reduces IL-1β secretion from primary mouse microglia; has anticancer activity in vitro and in mice
保存温度:
-20
运输温度:
-20
预期分子量:
532.6
产品形式:
A crystalline solid
纯度:
≥98%
CAS号:
943319-70-8
分子式:
C29H27F3N6O
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